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Position Governing Body Fellow Junior Research Fellow
School Clinical Medicine Cancer Research UK Cambridge Institute - CRUKCI
Email sean.flynn@cruk.cam.ac.uk
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Sean is a Junior Research Fellow and was previously a PhD student at �鶹��Ӿ�College. His research at the CRUK Cambridge Institute focuses on DNA structure and gene regulation.

Sean graduated with a BA in Human Genetics from Trinity College Dublin in 2013, and received his PhD from the University of Cambridge in 2018. For his PhD with Professor Mario de Bono at the MRC Laboratory of Molecular Biology, he identified genes and pathways that function in the nervous system using the small model organism C. elegans.

In 2020 he joined Professor Shankar Balasubramanian’s lab as a postdoctoral research associate at the CRUK Cambridge Institute, and in 2021 he was awarded a Leverhulme Trust Early Career Fellowship to investigate the biological functions of alternative DNA structures in the human genome.

In addition to the well-known double helix, DNA can form alternative structures such as the 4-stranded quadruplex. Although most of our DNA adopts a double helix, thousands of sites quadruplex structures form in our genome, like knots on a piece of string. However, their functions are not well understood. Sean is interested in understanding the role of quadruplex DNA in basic biological processes and identifying mechanisms by which it regulates gene expression.

Sean is based at the Cancer Research UK Cambridge Institute, where he uses genetic and genomics methods to study G-quadruplexes in human cells. He also works closely with colleagues at the Department of Chemistry.

What's on

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A triptych of three plant-themed paintings: the left shows large leaves, the center features a dark forest scene, and the right depicts vibrant, stylized foliage and flowers.

Art Exhibition: 'Life Within Landscapes'

21/09/2024 at 10.00

Explore Wolfson's newest exhibition, 'Life Within Landscapes', showcasing works by three Cambridge-based female contemporary artists, inspired by their Caribbean heritage.

Three women are engaged in a panel discussion on stage, seated on armchairs. A microphone, jug of water, and glasses are on the table in front of them.

A Woman's Place is in the Lab: Celebrating Women in STEM

28/09/2024 at 14.00

Celebrate Professor Jane Clarke’s legacy in STEM and join her for a discussion with four female scientists at different career stages about increasing accessibility for women in the field.